Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia; Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University Olomouc, Czech Republic
Title of the talk: Advances in investigation of antimicrobial multi-target compounds
Abstract
Multi-target drug discovery represents an innovative approach of medicinal chemistry to overcoming a crisis in drug design, especially of anti-invasive drugs, reflected in the small number of newly approved drugs. This approach is based on the concepts of privileged scaffolds, polypharmacology and multifactorial diseases. This approach seems to be a very useful tool in the design of antineoplastic and anti-infectious agents, as therapeutic agents designed in this way interact with multiple targets and thus prevent resistance, acting against various classes of pathogens and simultaneously against tumor cells. Similarly, multi-target drugs are designed for the simultaneous treatment of autoimmune, inflammatory and invasive diseases. This contribution is focused especially on the investigation of new ring-substituted anilides and carbamates of arylalkyl acids with estimated antimicrobial and anti-inflammatory activity. Structure-activity relationships and the supposed mechanism of action are discussed. In addition, attention is paid to new agents that are able to restore the effect of clinically used antimicrobial drugs in combination with them or demonstrate synergistic antimicrobial properties together with the drugs.
This study was supported by the Slovak Research and Development Agency (APVV-17-0373 and APVV-17-0318) and by the Ministry of Education of the Czech Republic (LO1305).
Biography
Josef Jampilek completed his Ph.D. degree in Medicinal Chemistry at the Faculty of Pharmacy of the Charles University (Czech Republic) in 2004. In 2004-2011, he worked in expert and managerial posts in the R&D Division of the pharmaceutical company Zentiva (Czech Republic). Prof. Jampilek deepened his professional knowledge at the Medicinal Chemistry Institute of the Heidelberg University (Germany) and at multiple specialized courses. In 2009, he became an Associate Professor of Medicinal Chemistry at the Faculty of Pharmacy of the University of Veterinary and Pharmaceutical Sciences Brno (Czech Republic). In 2017, he became a Full Professor of Medicinal Chemistry at the Faculty of Pharmacy of the Comenius University (Slovakia). He is an author/co-author of more than 30 patents/patent applications, more than 170 peer-reviewed scientific publications, 7 university textbooks, 20 chapters in monographs, and many invited lectures at international conferences and workshops. He also received several awards for his scientific results, e.g., from Aventis, Elsevier, Willey and Sanofi. The research interests of Prof. Jampilek include design, synthesis, and structure-activity relationships of heterocyclic compounds as anti-infectious and antiproliferative agents as well as photosynthesis inhibitors. He is also interested in ADME and drug bioavailability.
Information: ORCID, Researchgate.